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1.
J Clin Med ; 12(24)2023 Dec 18.
Artículo en Inglés | MEDLINE | ID: mdl-38137815

RESUMEN

BACKGROUND: Retrospective studies support that mean perfusion pressure (MPP) deficit in cardiac surgery patients is associated with a higher incidence of acute kidney injury (CS-AKI). The aim of our study was to apply an algorithm based on MPP in the postoperative period to determine whether management with an individualized target reduces the incidence of CS-AKI. METHODS: Randomized controlled trial of patients undergoing cardiac surgery with extracorporeal circulation. Adult patients submitted to valve replacement and/or bypass surgery with a high risk of CS-AKI evaluated by a Leicester score >30 were randomized to follow a target MPP of >75% of the calculated baseline or a standard hemodynamic management during the first postoperative 24 h. RESULTS: Ninety-eight patients with an eGFR of 54 mL/min were included. There were no differences in MAP and MPP in the first 24 h between the randomized groups, although a higher use of noradrenaline was found in the intervention arm (38.78 vs. 63.27, p = 0.026). The percentage of time with MPP < 75% of measured baseline was similar in both groups (10 vs. 12.7%, p = 0.811). MAP during surgery was higher in the intervention group (73 vs. 77 mmHg, p = 0.008). The global incidence of CS-AKI was 36.7%, being 38.6% in the intervention group and 34.6% in the control group (p = 0.40). There were no differences in extrarenal complications between groups as well. CONCLUSION: An individualized hemodynamic management based on MPP compared to standard treatment in cardiac surgery patients was safe but did not reduce the incidence of CS-AKI in our study.

2.
Rev Esp Cardiol (Engl Ed) ; 76(1): 32-39, 2023 Jan.
Artículo en Inglés, Español | MEDLINE | ID: mdl-35732565

RESUMEN

INTRODUCTION AND OBJECTIVES: Surgical aortic valve replacement (SAVR) can modify the natural history of severe aortic stenosis (SAS). However, compared with the general population, these patients have a loss of life expectancy. The life expectancy of patients who undergo SAVR due to low-gradient SAS with preserved left ventricular ejection fraction (LVEF) is unknown. METHODS: We included all patients between 50 and 65 years who underwent isolated SAVR in 27 Spanish centers during an 18-year period. We analyzed observed and expected survival at 18 years in patients with low-gradient SAS with preserved LVEF and all other types of SAS. We used propensity score matching to compare the life expectancy of patients with low-gradient SAS with preserved LVEF vs those with high-gradient SAS with preserved LVEF. RESULTS: We analyzed 5084 patients, of whom 413 had low-gradient SAS with preserved LVEF. For these patients, observed survival at 10, 15 and 18 years was 86.6% (95%CI, 85.3-87.8), 75% (95%CI, 72.7-77.2), and 63.5% (95%CI, 58.8-67.8). Expected survival at 10, 15 and 18 years was 90.2%, 82.1%, and 75.7%. In the matched sample, survival of patients with low-gradient SAS with preserved LVEF was similar to that of patients with high-gradient with preserved LVEF, log-rank test, P=.95; HR=1 (95%CI, 0.7-1.4; P=.95). CONCLUSIONS: There is a loss of life expectancy in patients with all types of SAS undergoing SAVR. This loss is higher in patients with left ventricular dysfunction and lower in patients with low-gradient or high-gradient aortic stenosis with preserved LVEF. The benefit of surgery is similar between these last 2 groups.


Asunto(s)
Estenosis de la Válvula Aórtica , Implantación de Prótesis de Válvulas Cardíacas , Humanos , Válvula Aórtica/diagnóstico por imagen , Válvula Aórtica/cirugía , Volumen Sistólico , Función Ventricular Izquierda , Resultado del Tratamiento , Pronóstico , Estenosis de la Válvula Aórtica/diagnóstico , Estenosis de la Válvula Aórtica/cirugía , Esperanza de Vida , Índice de Severidad de la Enfermedad , Estudios Retrospectivos
3.
Front Cardiovasc Med ; 9: 928090, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36386342

RESUMEN

Objectives: The aim of this study was to compare percutaneous catheter ablation vs. minimally invasive surgical ablation, evaluating the impact of repeated ablation on atrial function, and evaluating predictors of atrial fibrillation (AF) recurrence. Background: When AF ablation fails, re-ablations are required in up to 40% of patients to treat recurrent arrhythmia; surgical ablation is more effective than catheter ablation. Methods: Thirty-two patients with failed prior catheter ablation and referred for a second ablation (18 catheter and 14 surgical) were included in a descriptive observational study. Left atrial volumes, strain, and strain rate were measured with 2D speckle tracking echocardiography at baseline and 6 months after the procedures to assess left atrial functions. Patients received up to 1 year of clinical and Holter follow-up. Results: At the 12-month follow-up, catheter ablation was effective in 56% and surgical ablation in 72% of patients (OR 2 (CI 0.45-8.84), p 0.36). Left atrial booster function was similar in all patients, but left atrial reservoir function was more impaired in those patients who underwent surgical ablation. Left atrial booster function was predictive of arrhythmia recurrence after both catheter and surgical ablation: late diastolic strain rate (LASRa) cut-off ≤ -0.89 s-1 (sensitivity 88%, specificity 70%, AUC 0.82) and ≤ -0.85 s-1 (sensitivity 60%, specificity 100%, AUC 0.82), respectively. Conclusion: Surgical ablation has a more negative impact on LA reservoir function despite being slightly more effective in arrhythmia suppression. LA booster function is not significantly impaired by either procedure. LA booster function predicts arrhythmia elimination after a re-ablation (catheter or surgical).

4.
J Cardiothorac Vasc Anesth ; 36(8 Pt B): 3303-3311, 2022 08.
Artículo en Inglés | MEDLINE | ID: mdl-35618587

RESUMEN

Spontaneous coronary artery dissection is an uncommon, but not insignificant cause of acute coronary syndrome that overwhelmingly affects middle-aged women. The pathophysiology of coronary dissection appears to be an outside-in mechanism, where the initiating event is not an intimal tear but rather the formation of an intramural hematoma, which compromises blood flow by reducing the arterial lumen. Considering this mechanism, it is clear to see how intracoronary imaging techniques, such as optical coherence tomography and intravascular ultrasound, are most accurate in the diagnosis. However, they carry a high rate of complications and are therefore generally avoided when the clinical scenario and angiographic appearance both support the diagnosis of spontaneous coronary artery dissection. The natural history of the disease is toward healing of the vessel wall and restoration of blood flow. Therefore, conservative medical management is the preferred approach unless there are high-risk factors such as hemodynamic instability, signs of ischemia and severe proximal or multivessel lesions, in which percutaneous or surgical revascularization should be considered. Perioperative evaluation of these patients must take into account several aspects of this disease. Most of these patients will be receiving single or dual antiplatelet therapy, so one must consider the timing of the event and the surgical hemorrhagic risk when deciding to stop these therapies. Extracoronary vascular disease also must be assessed because it can have an effect on patient monitoring and risk of postoperative complications.


Asunto(s)
Anomalías de los Vasos Coronarios , Infarto del Miocardio , Enfermedades Vasculares , Angiografía Coronaria , Anomalías de los Vasos Coronarios/complicaciones , Anomalías de los Vasos Coronarios/diagnóstico por imagen , Vasos Coronarios , Femenino , Humanos , Persona de Mediana Edad , Infarto del Miocardio/complicaciones , Infarto del Miocardio/etiología , Enfermedades Vasculares/complicaciones , Enfermedades Vasculares/congénito , Enfermedades Vasculares/diagnóstico por imagen
5.
Ann Cardiothorac Surg ; 11(2): 151-160, 2022 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-35433371

RESUMEN

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) can be cured by pulmonary endarterectomy (PEA). It is considered the best and only curable treatment option for patients with accessible lesions evaluated as optimal candidates. We describe the experience of the two reference centers in Spain, in order to reinforce the need for referring CTEPH patients to a specialized center to be assessed by a Multidisciplinary Expert Team. Methods: We included a population of 338 patients who met the definition for CTEPH and underwent PEA between January 2007 and December 2019. The surgery was indicated in almost 60% of patients assessed. Demographic, anthropometric, hemodynamic and echocardiographic features are listed for PEA patients. Immediate and one-year postoperative outcomes as well as overall mortality were analyzed. Results: Mean age was 53.5±15.0 years, 53.8% were men; a total of 68.5% were in WHO functional class III-IV; and most of them were in a preoperative hemodynamic condition: mean pulmonary arterial pressure (mPAP) was 46.5±13.1 mmHg and mean pulmonary vascular resistance (PVR) was 764.5±392.8 dyn·s·cm-5. PEA surgery was performed with cardiopulmonary bypass (CBP) and circulatory arrest, with very few complications [including neurological, postoperative reperfusion edema, extracorporeal membrane oxygenation (ECMO) implant and cardiac failure] and optimal postoperative results, where exercise capacity increased and mPAP and PVR values decreased significantly. Presence of persistent pulmonary hypertension (PH) at the six-month right heart catheterization was evaluated. A 3.3% perioperative mortality was achieved. Overall, one-, three- and five-year survival rates were analyzed by Kaplan-Meier's method (94.8%, 93.3% and 90.5% respectively), as well as for residual PH patients. Mortality risk factors were assessed. Conclusions: Outstanding PEA results were seen in the immediate, one-year and long-term outcomes. The incidence of complications, including in-hospital mortality and long-term mortality were also below European rates.

6.
Rev Esp Cardiol (Engl Ed) ; 75(4): 294-299, 2022 Apr.
Artículo en Inglés, Español | MEDLINE | ID: mdl-34103259

RESUMEN

INTRODUCTION AND OBJECTIVES: In young patients with severe aortic stenosis, it is unknown whether their life expectancy restored after aortic valve replacement (AVR) is unknown. METHODS: We analyzed all patients aged between 50 and 65 years who underwent isolated AVR in 27 Spanish centers during an 18-year period. We compared observed and expected survival at 15 years of follow-up. We repeated all analyses for patients without complications in the postoperative period. RESULTS: A total of 5084 patients were analyzed. For the overall sample, observed survival at 10 and 15 years was 85.3% (95%CI, 84.1%-86.4%) and 73.7% (95%CI, 71.6%-75.6%), respectively. Expected survival was 90.1% and 82.1%. Cumulative relative survival for 1, 5, 10 and 15 years of follow-up was 97.4% (95%CI, 96.9%-97.9%), 96.5% (95%CI, 95.7%-97.3%), 94.7% (95%CI, 93.3%-95.9%), and 89.8% (95%CI, 87.3%-92.1%). For patients without complications, cumulative relative survival for 1, 5, 10 and 15 years was 100.3% (95%CI, 99.8%-100.5%), 98.9% (95%CI 97.6% -99.9%), 97.3% (95%CI, 94.9%-99.4%), and 91.9% (95%CI, 86.5%-96.8%). CONCLUSIONS: Life expectancy in young patients who have severe aortic stenosis and undergo AVR is lower than that of the general population. Life expectancy of individuals without complications during the postoperative period is also reduced. Therefore, baseline characteristics are likely the main factors that explain the reduction in life expectancy.


Asunto(s)
Estenosis de la Válvula Aórtica , Implantación de Prótesis de Válvulas Cardíacas , Prótesis Valvulares Cardíacas , Reemplazo de la Válvula Aórtica Transcatéter , Anciano , Válvula Aórtica/cirugía , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Humanos , Esperanza de Vida , Persona de Mediana Edad , Factores de Riesgo , Reemplazo de la Válvula Aórtica Transcatéter/efectos adversos , Resultado del Tratamiento
7.
Eur J Cardiothorac Surg ; 60(3): 681-688, 2021 09 11.
Artículo en Inglés | MEDLINE | ID: mdl-33772276

RESUMEN

OBJECTIVES: Some researchers have observed an increased number of deaths during the follow-up of young patients who undergo aortic valve replacement due to severe aortic stenosis, suggesting that this procedure does not restore their life expectancy. Our goal was to confirm these findings and explore sex-based differences. METHODS: All patients between 50 and 65 years of age who underwent isolated aortic valve replacement in 27 Spanish centres during an 18-year period were included. We compared observed and expected survival at 15 years of follow-up and estimated the cumulative incidence of death from a competing risks point of view. We stratified by sex and analysed if being a woman was an independent risk factor for death. RESULTS: For men, the observed survival at 10 and 15 years of follow-up was 85% [95% confidence interval (CI) 83.6%-86.4%] and 72.3% (95% CI 69.7%-74.7%), respectively whereas the expected survival was 88.1% and 78.8%. For women, the observed survival at 10 and 15 years was 85% (95% CI 82.8%-86.9%) and 73% (95% CI 69.1%-76.4%), whereas the expected survival was 94.6% and 89.4%. At 15 years of follow-up, the cumulative incidence of death due to the disease in men and women was 8.2% and 16.7%, respectively. In addition, being a woman was an independent risk factor for death (hazard ratio = 1.23 (95% CI 1.02-1.48; P = 0.03). CONCLUSIONS: After the aortic valve replacement, men and women do not have their life expectancy restored, but this loss is much higher in women than in men. In addition, being a woman is a risk factor for long-term death. Reasons for these findings are unknown and must be investigated.


Asunto(s)
Estenosis de la Válvula Aórtica , Implantación de Prótesis de Válvulas Cardíacas , Prótesis Valvulares Cardíacas , Reemplazo de la Válvula Aórtica Transcatéter , Válvula Aórtica/cirugía , Estenosis de la Válvula Aórtica/cirugía , Femenino , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Humanos , Esperanza de Vida , Masculino , Factores de Riesgo , Reemplazo de la Válvula Aórtica Transcatéter/efectos adversos , Resultado del Tratamiento
8.
Artículo en Inglés | MEDLINE | ID: mdl-30990581

RESUMEN

Cardiac fibromas are the second most common primary cardiac tumors in childhood. They only rarely present in adults. They are mainly located in the free wall of the ventricles and attached to the interventricular septum. Despite their benign pathology, fibromas in some locations can cause significant complications. This video tutorial illustrates the resection of a septo-apical cardiac fibroma in an asymptomatic 26-year-old woman, diagnosed with transthoracic echocardiography and cardiac magnetic resonance imaging after an abnormal ECG on an occupational medical examination. Surgery was performed through a median sternotomy using cardiopulmonary bypass. A nodular intramyocardial mass was found at the left ventricular apex and resection was carried out. After removing the fibroma, a defect was found at the apex affecting both ventricles. The defects were closed using a direct suture of 4-0 polypropylene "U" stitches reinforced with a Teflon patch to exclude the ventricular cavity.  Pathology confirmed the diagnosis of benign cardiac fibroma with tumor-free surgical margins. The patient recovered uneventfully and was discharged on postoperative day 5. The outpatient follow-up cMRI 10 months after surgery showed no signs of tumor recurrence and normal biventricular function.


Asunto(s)
Fibroma/diagnóstico por imagen , Fibroma/cirugía , Neoplasias Cardíacas/diagnóstico por imagen , Neoplasias Cardíacas/cirugía , Adulto , Puente Cardiopulmonar , Ecocardiografía , Femenino , Ventrículos Cardíacos , Humanos , Imagen por Resonancia Magnética , Esternotomía
9.
J Heart Valve Dis ; 25(1): 1-7, 2016 01.
Artículo en Inglés | MEDLINE | ID: mdl-29505225

RESUMEN

BACKGROUND AIM OF THE STUDY: The real burden of valvular heart disease (VHD) is scarcely known, as several factors may potentially lead to its increased prevalence. The study aim was to assess the prevalence of VHD and its treatment in the authors' environment to plan the healthcare requisites for optimal management of the condition. METHODS: A retrospective analysis was conducted of data acquired from patients who had been assessed at different consultation levels for cardiovascular disorders during a six-month period between January and June 2014 in public health referral area of 500,00 inhabitants. Patients included were those admitted to hospital cardiology, cardiac surgery and geriatric care units (n = 1,083), as well as ambulatory patients attending cardiology-specific outpatient clinics at the authors' hospital or at two ascribed primary care centers (n = 852). Data were registered regarding the epidemiology, etiology, echocardiography and treatment of patients in whom VHD was detected. RESULTS: Among a total of 1,935 adult patients, moderate or severe valve disease was identified in 453 cases (23.4%) who were evaluated for cardiovascular disease. The prevalence of VHD increased with age. Multivalvular moderate-severe dysfunction was present in two valves in 33% and in three valves in 5.7% of patients. Significant mitral valve disease was present in 39% and aortic valve disease in 48% of patients. The etiology of the valvular lesions was degenerative in 60%, functional in 15.5%, rheumatic in almost 10%, congenital in 6%, due to endocarditis in only 3%. Patients with VHD represented up to 24.2% of the in-hospital admissions. An interventional treatment was required in 55% of the patients (mostly surgical valve procedures). CONCLUSION: The present study results showed that VHD is a frequent occurrence and is increasingly prevalent with age, constituting up to one-fourth of all in-hospital admissions for cardiovascular disease. VHD is a growing public health problem that should be addressed with appropriate resources to improve research into its nature, diagnosis and treatment.


Asunto(s)
Servicio de Cardiología en Hospital/estadística & datos numéricos , Geriatría/estadística & datos numéricos , Enfermedades de las Válvulas Cardíacas/epidemiología , Adulto , Anciano , Anciano de 80 o más Años , Insuficiencia de la Válvula Aórtica/epidemiología , Estenosis de la Válvula Aórtica/epidemiología , Femenino , Enfermedades de las Válvulas Cardíacas/diagnóstico , Enfermedades de las Válvulas Cardíacas/terapia , Humanos , Masculino , Persona de Mediana Edad , Insuficiencia de la Válvula Mitral/epidemiología , Estenosis de la Válvula Mitral/epidemiología , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , España/epidemiología
10.
Arterioscler Thromb Vasc Biol ; 35(4): 960-72, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25593132

RESUMEN

OBJECTIVE: Marfan's syndrome is characterized by the formation of ascending aortic aneurysms resulting from altered assembly of extracellular matrix microfibrils and chronic tissue growth factor (TGF)-ß signaling. TGF-ß is a potent regulator of the vascular smooth muscle cell (VSMC) phenotype. We hypothesized that as a result of the chronic TGF-ß signaling, VSMC would alter their basal differentiation phenotype, which could facilitate the formation of aneurysms. This study explores whether Marfan's syndrome entails phenotypic alterations of VSMC and possible mechanisms at the subcellular level. APPROACH AND RESULTS: Immunohistochemical and Western blotting analyses of dilated aortas from Marfan patients showed overexpression of contractile protein markers (α-smooth muscle actin, smoothelin, smooth muscle protein 22 alpha, and calponin-1) and collagen I in comparison with healthy aortas. VSMC explanted from Marfan aortic aneurysms showed increased in vitro expression of these phenotypic markers and also of myocardin, a transcription factor essential for VSMC-specific differentiation. These alterations were generally reduced after pharmacological inhibition of the TGF-ß pathway. Marfan VSMC in culture showed more robust actin stress fibers and enhanced RhoA-GTP levels, which was accompanied by increased focal adhesion components and higher nuclear localization of myosin-related transcription factor A. Marfan VSMC and extracellular matrix measured by atomic force microscopy were both stiffer than their respective controls. CONCLUSIONS: In Marfan VSMC, both in tissue and in culture, there are variable TGF-ß-dependent phenotypic changes affecting contractile proteins and collagen I, leading to greater cellular and extracellular matrix stiffness. Altogether, these alterations may contribute to the known aortic rigidity that precedes or accompanies Marfan's syndrome aneurysm formation.


Asunto(s)
Aneurisma de la Aorta/etiología , Diferenciación Celular , Síndrome de Marfan/complicaciones , Músculo Liso Vascular/metabolismo , Miocitos del Músculo Liso/metabolismo , Actinas/metabolismo , Aorta/metabolismo , Aorta/patología , Aneurisma de la Aorta/metabolismo , Aneurisma de la Aorta/patología , Biomarcadores/metabolismo , Proteínas de Unión al Calcio/metabolismo , Estudios de Casos y Controles , Línea Celular Tumoral , Colágeno Tipo I/metabolismo , Proteínas del Citoesqueleto/metabolismo , Dilatación Patológica , Adhesiones Focales/metabolismo , Humanos , Síndrome de Marfan/metabolismo , Síndrome de Marfan/patología , Proteínas de Microfilamentos/metabolismo , Proteínas Musculares/metabolismo , Músculo Liso Vascular/patología , Miocitos del Músculo Liso/patología , Proteínas Nucleares/metabolismo , Fenotipo , Transducción de Señal , Fibras de Estrés/metabolismo , Transactivadores/metabolismo , Factor de Crecimiento Transformador beta/metabolismo , Remodelación Vascular , Proteína de Unión al GTP rhoA/metabolismo , Calponinas
11.
Interact Cardiovasc Thorac Surg ; 17(2): 353-8; discussion 358, 2013 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-23628652

RESUMEN

OBJECTIVES: To develop a multivariate predictive risk score of perioperative in-hospital stroke after coronary artery bypass grafting (CABG) surgery. METHOD: A total of 26 347 patients were enrolled from 21 Spanish hospital databases. Logistic regression analysis was used to predict the risk of perioperative stroke (ictus or transient ischaemic attack). The predictive scale was developed from a training set of data and validated by an independent test set, both selected randomly. The assessment of the accuracy of prediction was related to the area under the ROC curve. The variables considered were: preoperative (age, gender, diabetes mellitus, arterial hypertension, previous stroke, cardiac failure and/or left ventricular ejection fraction<40%, non-elective priority of surgery, extracardiac arteriopathy, chronic kidney failure and/or creatininemia≥2 mg/dl and atrial fibrillation) and intraoperative (on/off-pump). RESULTS: Global perioperative stroke incidence was 1.38%. Non-elective priority of surgery (priority; OR=2.32), vascular disease (arteriopathy; OR=1.37), cardiac failure (cardiac; OR=3.64) and chronic kidney failure (kidney; OR=6.78) were found to be independent risk factors for perioperative stroke in uni- and multivariate models in the training set of data; P<0.0001; AUC=0.77, 95% CI 0.73-0.82. The PACK2 stroke CABG score was established with 1 point for each item, except for chronic kidney failure with 2 points (range 0-5 points); AUC=0.76, 95% CI 0.72-0.80. In patients with PACK2 score≥2 points, off-pump reduced perioperative stoke incidence by 2.3% when compared with on-pump CABG. CONCLUSIONS: PACK2 risk scale shows good predictive accuracy in the data analysed and could be useful in clinical practice for decision making and patient selection.


Asunto(s)
Puente de Arteria Coronaria/efectos adversos , Técnicas de Apoyo para la Decisión , Accidente Cerebrovascular/epidemiología , Anciano , Anciano de 80 o más Años , Área Bajo la Curva , Distribución de Chi-Cuadrado , Femenino , Humanos , Incidencia , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Oportunidad Relativa , Selección de Paciente , Curva ROC , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , España/epidemiología , Resultado del Tratamiento
12.
Eur J Cardiothorac Surg ; 44(4): 725-31, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23435524

RESUMEN

OBJECTIVES: To determine the effect of the off-pump technique in preventing stroke development during the early perioperative period after coronary artery bypass graft surgery (CABG). METHODS: Patients undergoing isolated CABG surgery were enrolled from 21 Spanish cardiac-surgery centres. Baseline variables related to perioperative stroke risk were recorded in the preoperative (age, gender, diabetes mellitus, arterial hypertension, prior stroke, cardiac failure: preoperative New York Heart Association class III-IV and/or left ventricular ejection fraction <40%, non-elective priority of surgery, peripheral arteriopathy, chronic renal failure) and intraoperative periods (on/off-pump performance). The Northern New England Cardiovascular Disease Study Group (NNECDSG) stroke risk schema was used to stratify stroke risk and compare observed neurological outcomes in this study. RESULTS: A total of 26 347 patients were included in the study. Global perioperative stroke incidence was 1.38%. Non-elective priority of surgery (OR = 2.37), peripheral arteriopathy (OR = 1.62), cardiac failure (OR = 2.98), prior stroke (OR = 1.57) and chronic renal failure (OR = 6.16) were found to be independent risk factors for perioperative stroke in uni- and multivariate models; Hosmer-Lemeshow test: χ(2) = 4.62, P = 0.59. Perioperative stroke incidence increased whenever NNECDSG score or the number of preoperative risk factors increased. However, on- vs off-pump surgery did not show statistical differences in NNECDSG strata. For patients with two or more preoperative independent risk factors, off-pump surgery showed a significant reduction in perioperative stroke incidence (4.29 vs 6.76%, P < 0.05), particularly when one of these factors was chronic renal failure or preoperative cardiac failure. However, when both factors were present concomitantly there was no difference between on and off-pump techniques, P < 0.0001. CONCLUSIONS: Off-pump surgery has a lower perioperative stroke incidence than on-pump only in cases associated with cardiovascular stroke-risk factors, in particular, with chronic renal failure and preoperative cardiac failure, but also with peripheral arteriopathy, prior stroke and non-elective surgery. The perioperative stroke rate remains high in cases with two or more preoperative stroke risk factors, even when using the off-pump technique, particularly when chronic renal failure is present.


Asunto(s)
Puente de Arteria Coronaria Off-Pump/métodos , Accidente Cerebrovascular/prevención & control , Anciano , Anciano de 80 o más Años , Distribución de Chi-Cuadrado , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Periodo Perioperatorio , Estudios Retrospectivos , Factores de Riesgo
15.
Rev Enferm ; 33(4): 50-4, 2010 Apr.
Artículo en Español | MEDLINE | ID: mdl-20458895

RESUMEN

UNLABELLED: Accidental exposures to blood and biological material were the most frequent and potentially serious accidents in healthcare workers, reported in the Prevention of Occupational Risks Unit within 2002. BACKGROUND: Evaluate the biological percutaneous accidents decrease after a progressive introduction of safety devices. Biological accidents produced between 2.002 and 2.006 were analyzed and reported by the injured healthcare workers to the Level 2b Hospital Prevention of Occupational Risk Unit with 238 beds and 750 employees. The key of the study was the safety devices (peripheral i.v. catheter, needleless i.v. access device and capillary blood collection lancet). Within 2002, 54 percutaneous biological accidents were registered and 19 in 2006, that represents a 64.8% decreased. There has been no safety devices accident reported involving these material. Accidents registered during the implantation period occurred because safety devices were not used at that time. Safety devices have proven to be effective in reducing needle stick percutaneous accidents, so that they are a good choice in the primary prevention of biological accidents contact.


Asunto(s)
Accidentes de Trabajo/prevención & control , Derrame de Material Biológico/prevención & control , Lesiones por Pinchazo de Aguja/prevención & control , Equipos de Seguridad , Humanos
16.
Rev. Rol enferm ; 33(4): 290-294, abr. 2010. ilkus, graf
Artículo en Español | IBECS | ID: ibc-79297

RESUMEN

Las exposiciones accidentales con sangre y material biológico constituyeron los accidentes más frecuentes y potencialmente graves en el personal sanitario, notificados en la Unidad de Prevención de Riesgos Laborales en el año 2002. Objetivos: evaluar la efectividad, en cuanto a la disminución de accidentes biológicos percutáneos, tras la implantación progresiva de material de bioseguridad. Se analizaron los accidentes biológicos notificados de forma voluntaria por parte del trabajador accidentado, desde el año 2002 al 2006, al Servicio de Prevención de un hospital de nivel 2 b, con 238 camas polivalentes y una plantilla de 750 trabajadores. La variable del estudio fue el material de bioseguridad: catéter intravenoso periférico, sistema cerrado de acceso intravenoso sin aguja y lanceta de punción capilar. En el año 2002 se registraron 54 accidentes biológicos vía percutánea y 19 en el 2006 representando una reducción de un 64,8%. No se ha notificado ninguno en el que esté implicado el material de bioseguridad. Los registrados durante el periodo en el que se implantó dicho material se produjeron al no utilizarlo en ese momento. El material de bioseguridad ha demostrado ser efectivo para la disminución en la notificación de accidentes por punción percutánea, constituyendo una buena opción para la prevención primaria de los accidentes por contacto biológico(AU)


Accidental exposures to blood and biological material were the most frequent and potentially serious accidents in healthcare workers, reported in the Prevention of Occupational Risks Unit within 2002. Background: Evaluate the biological percutaneous accidents decrease after a progressive introduction of safety devices. Biological accidents produced between 2.002 and 2.006 were analyzed and reported by the injured healthcare workers to the Level 2b Hospital Prevention of Occupational Risk Unit with 238 beds and 750 employees. The key of the study was the safety devices (peripheral IV catheter, needleless IV access device and capillary blood collection lancet). Within 2002, 54 percutaneous biological accidents were registered and 19 in 2006, that represents a 64.8% decreased. There has been no safety devices accident reported involving these material. Accidents registered during the implantation period occurred because safety devices were not used at that time. Safety devices have proven to be effective in reducing needle stick percutaneous accidents, so that they are a good choice in the primary prevention of biological accidents contact(AU)


Asunto(s)
Humanos , Masculino , Femenino , Contención de Riesgos Biológicos/prevención & control , Contención de Riesgos Biológicos/políticas , Liberación de Radiactividad Peligrosa/prevención & control , Liberación de Radiactividad Peligrosa/tendencias , 35436 , Contaminación Biológica/métodos , Contaminación Biológica/prevención & control , Contaminación Biológica/políticas , Prevención de Accidentes/tendencias , Liberación de Peligros Químicos/prevención & control
17.
J Heart Lung Transplant ; 27(9): 984-9, 2008 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-18765190

RESUMEN

OBJECTIVE: This study assessed the role of heart transplantation (HTx) in the management of patients with acute myocardial infarction (MI) complicated by refractory cardiogenic shock despite percutaneous coronary intervention (PCI). The primary end-point of the study was mortality at the 1-year follow-up. METHODS: Between January 2001 and December 2005, 74 consecutive patients with acute MI complicated with cardiogenic shock were retrospectively analyzed. Thirty-nine patients did not have a contraindication for HTx and qualified for the study (age < 65 years, no comorbidities). RESULTS: Urgent HTx was performed in 10 patients. The remaining 29 patients served as controls. The HTx vs no HTx groups were well balanced in age (50 vs 53 years), proportion of multivessel disease (30% vs 10%), cardiac index (2.2 vs 2.4 liters/min/m(2)), and left ventricular ejection fraction (23% vs 25%). Mortality rates were significantly lower in the HTx group, both in the hospital (10% vs 45%, p < 0.03) and at 1 year (10% vs 52%, p < 0.03). Survival at 1 year among patients alive at hospital discharge was 100% in the HTx group vs 94% in the no HTx group. CONCLUSIONS: Urgent HTx dramatically improves survival of acute MI patients presenting with refractory cardiogenic shock despite early PCI. Therefore, this approach--wherever feasible--needs to be considered in the management of this particular subset of patients.


Asunto(s)
Trasplante de Corazón/fisiología , Infarto del Miocardio/complicaciones , Infarto del Miocardio/cirugía , Choque Cardiogénico/cirugía , Adulto , Factores de Edad , Presión Sanguínea , Índice de Masa Corporal , Femenino , Frecuencia Cardíaca , Trasplante de Corazón/mortalidad , Hemodinámica , Humanos , Estilo de Vida , Masculino , Persona de Mediana Edad , Selección de Paciente , Estudios Retrospectivos , Choque Cardiogénico/etiología , Choque Cardiogénico/terapia , Sobrevivientes , Resultado del Tratamiento
18.
Rev. calid. asist ; 18(5): 286-290, ago. 2003. tab
Artículo en Español | IBECS | ID: ibc-143589

RESUMEN

Fundamentos: Después de la aplicación de medidas de calidad se comparó la calidad percibida por los usuarios del servicio de urgencias de nuestro hospital en el año 2000 con la percibida por los usuarios en el año 1998. A su vez se compararon los datos globales de los servicios de urgencias del grupo de hospitales del Institut Català de la Salut (ICS) con los de nuestro centro. Material y métodos: Se realizaron dos encuestas telefónicas centralizadas desde el ICS a los usuarios del servicio de urgencias, la primera en el año 1998 y la segunda en el año 2000. Sobre una muestra de 3.811 pacientes, a nuestro centro le correspondieron 218 en el año 1998 y 213 en el 2000. Las dimensiones valoradas fueron: accesibilidad, trato, información, confort, competencia profesional, confianza y satisfacción global. Resultados: Al comparar los resultados de nuestro centro del año 2000 con los del año 1998, se observó que en sólo 2 preguntas (información del tiempo de espera y confort del lugar de las exploraciones) se obtuvieron mejoras estadísticamente significativas, y en una pregunta se observó un empeoramiento. En relación con el global de hospitales del ICS, en 11 preguntas se obtuvieron mejores puntuaciones estadísticamente significativas, entre ellas la de satisfacción global, destacando como la mejor la dimensión trato. Conclusiones: En todos los aspectos relevantes se obtuvieron mejores resultados que en el global de los hospitales del ICS, pero con capacidad de mejora en aspectos informativos a los pacientes. A pesar de la introducción de aspectos de mejora de la calidad, los resultados obtenidos en la encuesta del año 2000 no muestran una mejora significativa en la mayoría de las dimensiones valoradas en relación con la encuesta del año 1998 (AU)


Background: Users’ perception of quality of the Emergency Room service in our hospital in 2000 was compared with that in 1998 after the application of quality measures. Global data on the Emergency Room services of the Catalan Health Institute [Institut Català de la Salut (ICS)] hospital division were compared with those from our center. Material and methods: Two telephone surveys, centralized by the ICS, of users of Emergency Room services were performed. The first survey was performed in 1998 and the second in 2000. Of a sample of 3811 patients, 218 patients received medical assistance in our center in 1998 and 213 in 2000. The dimensions evaluated were: accessibility, dealings with staff, verbal and written information, comfort, professional competence, confidence, and global satisfaction. Results: Comparison of the results of the 2000 survey with those for 1998 in our center revealed that statistically significant improvements were obtained in only two items (information on waiting times and comfort) and that in one item a lowering of standards was observed. The hospitals of the ICS obtained statistically significant improvements in scores of eleven questions, among them, global satisfaction. The item receiving the highest score was that concerning dealings with staff. Conclusions: In all salient aspects, the results obtained in our center were better than the global score for the ICS hospital division. The information given to patients could be improved. Despite quality improvement, the results obtained in the 2000 survey were not significantly better than those obtained in most of the dimensions evaluated in the 1998 survey (AU)


Asunto(s)
Humanos , Tratamiento de Urgencia/estadística & datos numéricos , Servicios Médicos de Urgencia/estadística & datos numéricos , Calidad de la Atención de Salud/estadística & datos numéricos , Satisfacción del Paciente , Encuestas de Atención de la Salud/estadística & datos numéricos , Teléfono , Indicadores de Calidad de la Atención de Salud
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